Marvel has recently decided to revert the numbering of Fantastic Four back to its original number, that is, what the number would have been without reboots and volume changes, etc. This is likely to become a trend: as Amazing Spider-Man quickly approaches that same number, it too may revert to the original numbering. That would mean Amazing Spider-Man Volume 2 #59 would be renumbered to #500.
For more details and comments from Marvel, check out this article at Newsarama.